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KMID : 1377020200170060901
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Tissue Engineering and Regenerative Medicine
2020 Volume.17 No. 6 p.901 ~ p.908
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Articular Cartilage Regeneration Utilizing Decellularized Human Placental Scaffold, Mesenchymal Stem Cells and Platelet Rich Plasma
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Ozdemir Erdi
Emet Abdulsamet
Hashemihesar Ramin
Yuruker Ali Celalettin Sinan
Kilic Emine
Cetinkaya Duygu Uckan
Turhan Egemen
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Abstract
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Background: Articular cartilage repair has been a challenge in orthopedic practice due to the limited self-regenerative capability. Optimal treatment method for cartilage defects has not been defined. We investigated the effect of decellularized human placental (DHP) scaffold, mesenchymal stem cells (MSC) and platelet-rich plasma (PRP) on hyaline cartilage regeneration in a rat model.
Methods: An osteochondral defect was created in trochlea region of the femur in all groups, bilaterally. No additional procedure was performed in control group (n?=?14). Only the DHP scaffold was applied to the P group (n?=?14). The DHP scaffold and 1?×?106 MSCs were applied to the PS group (n?=?14). The DHP scaffold and PRP were applied to the PP group (n?=?14). The DHP scaffold, 1?×?106 MSCs and PRP were applied to the PSP group (n?=?14). Outcome measures at 12 weeks included Pineda histology score and qualitative histology.
Results: The mean Pineda scores of P, PS, PP, and PSP groups were significantly better than the control group (p?=?0.031, p?=?0.002, p??0.05).
Conclusion: In conclusion, the DHP scaffold appears to be a promising scaffold on hyaline cartilage regeneration. The augmentation of DHP scaffold with MSCs and PRP combinations did not enhance its efficacy on articular cartilage regeneration.
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KEYWORD
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Cartilage, Placenta decellularization, Platelet-rich plasma, Mesenchymal stem cells
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